Multi-tasking Unique Copolymers for Imaging Toxicants and Enzymes for Health Care Applications

Das, Narayan (2024) Multi-tasking Unique Copolymers for Imaging Toxicants and Enzymes for Health Care Applications. PhD thesis, Indian Institute of Science Education and Research Kolkata.

Text (PhD thesis of Narayan Das (18RS082)) 18RS082.pdf - Submitted Version Restricted to Repository staff only Download (9MB)

Abstract

Toxicants are harmful toxic materials that mainly create adverse biological impacts on the environment and human health, originating artificially or naturally. Because of the economic advancement of human civilization and rapid development in different sectors such as industry, agriculture, and mining, the environment is contaminated which causes detrimental effects on the environment and human health. Toxicants can be in different shapes, forms, and sizes which include various ranges of inorganic substances, heavy metals, and organic substances like pharmaceutical medicines. Environmental toxicants enter the environment and human food cycle mainly by both natural and anthropogenic sources through certain activities such as waste burning, synthetic industries, and coal conversions which create dangerous effects for biotic societies (humans, animals, and plants) and abiotic elements (water, air, and soil). Environmental contamination is one of the main reasons that cause high morbidity, mortality, and diseases in many nations across different parts of the world. According to a report published by the World Health Organization which says that around a million deaths happen because of environmental toxicants. Very commonly metallic and non-metallic toxicants enter our bodies with contaminated food and over a long period of consumption of this contaminated food which contains highly concentrated toxins causes infection in the gastrointestinal tract, and upper and lower intestines. The toxins inside the contaminated food act as a transport system for the pathogens and offer a platform where these pathogens can multiply themselves in larger numbers. The bacterial infection in the gastrointestinal track over a long period causes harmful health complications in our body even colon cancer. In case of the colon cancer, a particular enzyme is highly elevated, named as azoreductase. In this report, we have developed a polymer-based detecting system and its molecular unique self-assembly for the selective and sensitive identification, removal, and monitoring the harmful toxicants like copper, hydrazine, and hypochlorite ions and overexpressed enzymes like azoreductase to early remove the threat of the cancer related to colon and lower intestine.

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