Norbornene-Based Polymeric Biosensor for Hydrogen Sulfide Sensing and Bio-Imaging

Mohanty, Srujana (2023) Norbornene-Based Polymeric Biosensor for Hydrogen Sulfide Sensing and Bio-Imaging. Masters thesis, Indian Institute of Science Education and Research Kolkata.

Text (MS disertation of Srujana Mohanty (18MS184)) Thesis_18MS184.pdf - Submitted Version Restricted to Repository staff only Download (4MB)

Abstract

A highly efficacious fluorescent chemosensor has been synthesized, predicated on a biodegradable and biocompatible norbornene derivative. The superiority of polymeric sensors over their monomeric counterparts lies in their enhanced solubility, expedited response time, and exceptional detection limit. Chapter 1 provides a concise introduction to macromolecules and chemosensors, while Chapter 2 delves into the synthesis, characterization, and results pertaining to monomer and the polymer. The reaction-based system results in the observation of fluorescence upon reaction with H₂S. Following the interaction with H₂S, the sensor monomer fluorescence, thereby leading to the regeneration of the precursor molecule. Chapter 3 offers a comprehensive overview of the study’s results and discussion. The synthesized molecules were characterized utilizing ¹H NMR, ¹³C, and mass spectroscopy. Both the monomer and polymer effectively detected hydrogen sulfide in solution, as confirmed through an array of selective studies.

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