Maity, Sayantan (2021) Understanding the Mechanisms Behind Cell Sorting and Cell Migration. Masters thesis, Indian Institute of Science Education and Research Kolkata.
![[img]](http://eprints.iiserkol.ac.in/style/images/fileicons/text.png) |
Text (MS Dissertation of Sayantan Maity (16MS061))
16MS061_Thesis_file.pdf - Submitted Version Restricted to Repository staff only Download (4MB) |
Abstract
Different kinds of cells are observed in physiological systems to segregate and generate cellular layers or different tissues. In this work, we investigate the dependence of this cellular sorting phenomena on cell-cell cohesion, cell-matrix adhesion, and the interfacial tension of the cells using the theoretical framework of the Cellular Potts Model. Starting from a similar randomized configuration and using different sets of adhesion-cohesion energies, we see that the system dynamically evolves into a cellular segregation configuration. Further, it takes different times to reach the steady-state configuration. Moreover, in biological tissues, the cells fixed at their positions may suddenly move to other places in different scenarios (for example, in case of wound healing or cancer metastasis). This behaviour mimics the transition of the cells from a solidlike state to a liquid-like state. We study the dependence of collective migration of cells in a confluent monolayer using the same theoretical framework of the Cellular Potts Model, on cell-cell adhesion, surface energy minimization, motility energy, and also the characteristic noise present in the cellular microenvironment. We have studied the collective cellular dynamics using correlated noise with different correlation times to find the dependence of solid to liquid transition of the cells on the correlation time. To compare our model with a physiological system containing a large number of cells, we imposed a periodic boundary condition and observed the dynamics of the cells on the same, in the presence of both uncorrelated and correlated noise
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | Supervisor: Dr. Rumi De |
| Uncontrolled Keywords: | Adhesion energy, Cohesion energy, Cellular Potts Model, Confluent Monolayer, Gaussian White Noise, Correlated Noise, Periodic Boundary Condition. |
| Subjects: | Q Science > QC Physics |
| Divisions: | Department of Physical Sciences |
| Depositing User: | IISER Kolkata Librarian |
| Date Deposited: | 23 Sep 2025 10:46 |
| Last Modified: | 23 Sep 2025 10:46 |
| URI: | http://eprints.iiserkol.ac.in/id/eprint/1791 |
Actions (login required)
 |
View Item |
