Towards the total synthesis of the target trisaccharide repeating unit isolated from Fusobacterium nucleatum strain 10953

Biswas, Utsho (2025) Towards the total synthesis of the target trisaccharide repeating unit isolated from Fusobacterium nucleatum strain 10953. Masters thesis, Indian Institute of Science Education and Research Kolkata.

Text (MS Dissertation of Utsho Biswas (20MS144)) 20MS144_Thesis_file.pdf - Submitted Version Restricted to Repository staff only Download (5MB)

Abstract

Chapter 1: General Introduction This chapter gives a complete picture of carbohydrates, covering their chemical structure, classification (monosaccharides, disaccharides, oligosaccharides, polysaccharides), and their critical functions in biological systems. It emphasizes carbohydrate functions in energy storage, structural support, cell signaling, and immunity. Chapter 2: Glycosylation Techniques The second chapter discusses the different ways of glycosylation-the method through which carbohydrates are enzymatically or chemically linked to proteins and lipids. It describes the mechanisms, types (N-linked, O-linked), and importance of glycosylation in biological processes and analytical methods used to investigate glycosylated biomolecules. Chapter 3: Characterization of a trisaccharide repeating unit This chapter illustrates the efforts Towards the total synthesis of the target trisaccharide repeating unit isolated from Fusobacterium nucleatum strain 10953. Completed till the protecting trisaccharide with protecting groups. Plan for the remaining synthesis is discussed as future work.

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