Peptide-Based Regenerative Medicines for Comprehensive Wound Care

Jan, Somnath (2026) Peptide-Based Regenerative Medicines for Comprehensive Wound Care. PhD thesis, Indian Institute of Science Education and Research Kolkata.

Text (PhD thesis of Somnath Jan (19RS050)) 19RS050.pdf - Submitted Version Restricted to Repository staff only Download (34MB)

Abstract

Unregulated excessive bleeding and delayed wound healing cause serious health hazards due to lack of comprehensive wound care. Currently, safe, adhesive and minimally invasive comprehensive wound care is not available, which offers dual benefits by performing very efficiently on-demand hemostatic sealing and simultaneously performs wound healing. Uncontrolled bleeding is a leading cause of mortality among accident victims, injured military personnel, and patients having inherent bleeding disorders. Many existing hemostats are difficult to apply or may trigger exothermic reactions. Moreover, their limited effectiveness, risk of allergic responses, potential disease transmission, and storage constraints highlight the urgent need for a biocompatible, easy-to-use wound care material that can effectively promote both rapid blood clotting and accelerated healing. To address the issues of traumatic coagulopathy and inherent bleeding disorder, we have designed improved biocompatible adhesive peptide based hemostatic agents to accelerate blood clotting. These peptide-based sealants form a physical barrier at the injury site, absorbing blood fluid, concentrating blood corpuscles and platelets, and effectively stop bleeding by forming hemostatic plug only at injured site. Additionally, chronic non-healing diabetic wounds pose significant healthcare challenges, often resulting in pain, suffering, and diminished quality of life. Growth factor-mimetic peptide-based functional biomaterials hold great promise for engineering improved proangiogenic therapy. To overcome the challenges of non-healing diabetic wound, we have designed growth-factor mimetic stabilised peptides, which can promote wound healing by implementing therapeutic angiogenesis. Designed angiogenic peptides co-administered with peptide-based hemostat can exhibit faster blood-clotting, followed by accelerated wound healing. Such nature-inspired peptide-based cost-effective wound care may have immense translational potential as clinically safe “comprehensive wound care”.

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