Synthesis of Biologically Active Oligosaccharides from Plant and Bacterial Origin

Budhadev, Darshita (2015) Synthesis of Biologically Active Oligosaccharides from Plant and Bacterial Origin. PhD thesis, Indian Institute of Science Education and Research Kolkata.

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Abstract

Chapter 1 illustrates the significance of carbohydrates in various life processes, their applications in modern day therapeutics and the emergence of a new area of research called ‘glycomics’. Chapter 2 demonstrates the recent development in glycosylation strategies, the key to the synthetic carbohydrate chemistry. The main focus is given on the activation of glycosyl halides, thioglycosides and glycosyl trichloroacetimidates. Chapter 3 describes the total synthesis of two trisaccharides related to the hepatoprotective phenylethanoids leonoside E and F isolated from Leonurus japonicas Houtt. in the form of its 4- methoxyphenyl glycoside. Chapter 4 details the chemical synthesis of a tetrasaccharide related to the exocellular polysaccharide from Rhodococcus sp. RHA1 in the form of its 4-methoxyphenyl glycoside. Chapter 5 illustrates the chemical synthesis of a pentasaccharide related to the repeating unit of the O-antigen of Enterobacter cloacae G2277 in the form of its 4-methoxyphenyl glycoside. Chapter 6 describes the chemical synthesis of a hexasaccharide related to the repeating unit of the Oantigen of Escherichia coli O120 in the form of its 4-methoxyphenyl glycoside.

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