Efficient Design to Monitor the Site Specific Sustained Release of Colorless/Non-emissive Cancer Drug

Venu, Parvathy (2015) Efficient Design to Monitor the Site Specific Sustained Release of Colorless/Non-emissive Cancer Drug. Masters thesis, Indian Institute of Science Education and Research Kolkata.

PDF (MS dissertation of Parvathy Venu (10MS69)) Parvathy_Venu-10MS69.pdf - Submitted Version Restricted to Repository staff only Download (12MB)

Abstract

In the recent decades, polymers are widely used as biomaterials due to their favorable properties such as good biocompatibility, easy design and preparation, a variety of structures and interesting bio-mimetic character. In our design, we have used Folate with poly ethylene glycol for making the system site specific as well as water soluble. Folate which is present in our polymer system will have a tendency to the cancer cells which are possessing folate receptors As I mentioned earlier, one of the main characteristics of cancer cells are, the presence of more folate receptors. Therefore we are using this particular feature for making our system site specific. In our design, we have used methyl orange because the anticancer drug which we have attached is not emissive in nature, therefore we have used orange in our system for making our system exhibits color. Methyl orange molecule is attached to the norbornene and is polymerized using technique, ROMP. The objective of the present thesis is to synthesize a stimuli responsive anti-cancer drug derived nano-carrier by conjugating chlorambucil, peg-folate and methyl orange to the backbone of a norbornene polymer Towards the goal, there are three monomers namely, norbornene-chlorambucil (NOR-CHO), norbornene –grafted polyethylene glycol folate (NOR-PEG-FOL) and norbornene attached with methyl orange (NOR-METH) are synthesized.The CHO motif is connected to norbornene backbone by ester linker to demonstrate the pH responsive capabilities. The newly designed monomers are expected to undergo Ring Opening Metathesis Polymerization (ROMP) due to the exceptional functional group tolerance of the Grubbs' catalyst, and the resultant stimuli responsive nanocarrier is expected to serve as a smart drug delivery vechicle for cancer. The presence of the PEG–FOL functionality makes the system water-soluble as well as sitespecific in nature. Methyl Orange, a well known sulfonated azo dye which I have used in our system makes the nanocarrier exhibiting color since the anticancer drug chlorambucil is not emissive in nature.

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