Nano Materials From Folded Peptides

Pramanik, Apurba (2017) Nano Materials From Folded Peptides. PhD thesis, Indian Institute of Science Education and Research Kolkata.

PDF (PhD thesis of Apurba Pramanik) Apurba_Pramanik_Thesis.pdf - Submitted Version Restricted to Repository staff only Download (4MB)

Abstract

Self-assembling peptides can give rise to a variety of supramolecular architectures like supramolecular helix, supramolecular β-sheets and others, which have potential importance in biological as well as material sciences. Previous studies suggested that self-assembles peptide β-sheet structures and helices have a role in highly ordered selfaggregated fibril formation in amyloid disease like neurodegenerative disorders including Alzheimer’s disease, Perkinson’s disease and Prion-related encephalopathies and others. So, the study of molecular self-assembly of synthetic peptides is highly important. Self-assembling peptides are one of the most attractive and useful building blocks in making various nanostructures including nanotubes, nanorods, nanovesicles, nanobelts, nanofibers and others because of their chemical diversity, biocompatibility, biodegradability and foldability into specific structures. These nanostructure formations are depend on the sequence as well as environmental responses. These peptide based building blocks can be self-assembled in various solvent using various noncovalent interactions including hydrogen bonds, π-π stacking interactions, electrostatic interactions and hydrophobic interactions to form a specific type of nanostructure depending on suitable conditions. The main aim of this thesis was to use synthesis peptides composed of genetically coded and / or noncoded amino acids for studying and understanding molecular self-assembly processes of these peptides in diverse nanomaterials, gels and their versatile applications.

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