Multicomponent Functional Solids and Their Structure-property Relationship: Crystal Engineering

Ranjan, Subham (2017) Multicomponent Functional Solids and Their Structure-property Relationship: Crystal Engineering. Masters thesis, Indian Institute of Science Education and Research Kolkata.

PDF (MS dissertation of Subham Ranjan (12MS050)) Subham_Ranjan_MS_Thesis.pdf - Submitted Version Restricted to Repository staff only Download (8MB)

Abstract

Crystal engineering has emerged as the most advanced aspect of solid state chemistry owing to its numerous applications in diverse fields. In this context, I tried to explore the broad spectrum of crystal engineering implications in designing new solid forms with desired properties. Chapter 1 provides a brief overview about crystal engineering and its various applications. Chapter 2 describes about a crystal engineering approach to design multicomponent solid form of a poorly soluble drug, hydrochlorothiazide so as to tune its poor physicochemical properties. Chapter 3 demonstrates a study of isomorphism in multicomponent solids of mefenamic acid and tolfenamic acid and using the resulting crystal structural landscape for finding the hidden forms of the parent APIs. Chapter 4 describes about the structure-mechanical property relationship of three polymorphs of a Schiff base of isatin. Further, the thermal responses were investigated for the three polymorphs.

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