Design of Supramolecular Amphiphiles in Aqueous Medium Using Cucurbiturils

Kumar, Anubhav (2018) Design of Supramolecular Amphiphiles in Aqueous Medium Using Cucurbiturils. Masters thesis, Indian Institute of Science Education and Research Kolkata.

PDF (MS dissertation of Anubhav Kumar (13MS036)) 13MS036.pdf - Submitted Version Restricted to Repository staff only Download (2MB)

Abstract

The research work embodied in this thesis is based on the design of supramolecular amphiphiles on preliminary existing knowledge from an extensive literature survey. The first part of the thesis focuses on the synthesis of amphiphilic molecules capable of forming self-assembled ordered micelles in aqueous media followed by characterization of the initially synthesized molecules using well-known techniques of Infrared and Nuclear Magnetic Resonance (NMR) Spectroscopy. The second part of the thesis explores the host-guest complexation by Fluorescence Spectroscopy and Dynamic Light Scattering (DLS) experiments (The host molecule being of a specific family, Cucurbiturils CB[n] in our case). From the consistent variation in fluorescence intensities upon increasing concentrations of the host molecules (with a fixed concentration of the guest), we can conclude of a successful host-guest complexation with reasonably high binding constants (K =10⁵ -10⁷ M⁻¹). The DLS experiments established the approximate concentration region where the formation of the aggregates is initiated.

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