Self-Assembled Chromophore Appended Imidazolium Amphiphiles for sensing of Biological Analytes

Ghosh, Surya (2019) Self-Assembled Chromophore Appended Imidazolium Amphiphiles for sensing of Biological Analytes. Masters thesis, Indian Institute of Science Education and Research Kolkata.

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Abstract

A simple yet novel amphiphilic imidazolium-based system was designed which could sense ATP selectively among other biological analytes in micromolar range in a competitive environment like water. It is based on the principal of multivalency which is a powerful weapon by which we can increase the binding affinity for weak receptor sites. Sensing of biological analytes is not a new phenomenon but reports of using self-assembled systems to recognize them in water are very few and are the growing areas of research in sensing at the time. ATP is involved in many cellular processes in the body and is known as the energy currency of the cell. Monitoring the ATP levels in the body would help one to have knowledge on the calories taken and spent on a regular basis. Therefore, the selective sensing of ATP in aqueous environment is very challenging and as well as of very high importance. Imidazolium based phosphate receptors are known in literature for the sensing of biological analytes but the detection limit reported are not very high. So herein we have tried to solve the problem by utilising the same receptor sites but by multivalent approach of the self-assembled systems.

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