Caprolactone based functional monomers and amphiphiliic copolymers for engineering self-assembled superstructures

Chethalen, Roshni J. (2019) Caprolactone based functional monomers and amphiphiliic copolymers for engineering self-assembled superstructures. Masters thesis, Indian Institute of Science Education and Research Kolkata.

PDF (MS dissertatiion of Roshni J Chethalen (14MS097)) 14MS097.pdf - Submitted Version Restricted to Repository staff only Download (2MB)

Abstract

A new set of amphiphilic copolymers based on caprolactone and polyethylene glycol monomethyl ether has been synthesized in order to ensure biocompatibility and biodegradability of the polymer scaffold through ester linkages which makes it stimuli responsive. Synthesis of PCAP-INI-PEG was done by ring opening polymerization (ROP) of Caprolcatone using Sn(oct)2 catalyst. Polycaprolactone is attached to both the arms and polyethylene glycol monomethyl ether is attached to the central amine group of the macroinitiator. Synthesis of PCAP-POLYCLICK was done by treating 2,2 bis(bromomethyl) propan-1,3-diol with sodium azide which was followed by click chemistry. Click chemistry being stereospecific, simple to perform, wide in scope and most importantly high yielding is a very productive method used in synthetic chemistry. Caprolactone (hydrophobic) and polyethylene glycol derivative (hydrophilic) was carefully chosen to incorporate amphiphilicity to the system so that it will guarantee well organized self-assembled structures. The synthesized compounds were characterized using 1H NMR, FT-IR Spectroscopy. Polymerization was confirmed using APC and the aggregation studies were done using Critical Aggregation Concentration, Dynamic Light Scattering and Field Emission- Scanning Electron Microscopy (FE-SEM).

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