Abnormal N-Heterocyclic Carbene Based Potassium Complex for Reduction of Primary Amides

Sahoo, Sumeet Ranjan (2019) Abnormal N-Heterocyclic Carbene Based Potassium Complex for Reduction of Primary Amides. Masters thesis, Indian Institute of Science Education and Research Kolkata.

PDF (MS dissertation of Sumeet Ranjan Sahoo (14MS010)) 14MS010.pdf - Submitted Version Restricted to Repository staff only Download (1MB)

Abstract

An abnormal N-heterocyclic carbene (aNHC) based potassium complex, 1 has been used as transion metal-free catalyst for the reduction of primary amides to corresponding primary amides under ambient conditions. A catalytically active intermediate [aNHC-HBPin] was isolated and characterized through NMR as well as single-crystal XRD. Low catalyst loading exhibits a broad substrates scope including aliphatic primary amides with excellent functional group tolerance. Well-defined pre-catalyst and isolable intermediate along the reduction pathway have helped to sketch the mechanistic pathway for primary amides reduction.

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