Effect of Anti-Inflammatory Homeopathic Medicines on Border Cell Migration

Raha, Titas (2025) Effect of Anti-Inflammatory Homeopathic Medicines on Border Cell Migration. Masters thesis, Indian Institute of Science Education and Research Kolkata.

Text (MS Dissertation of Titas Raha (20MS004)) 20MS004_Thesis_file.pdf Restricted to Repository staff only Download (1MB)

Abstract

Cell migration is one of the fundamental processes integral to the development of metazoans. It is the foundation for vital processes like wound healing, gastrulation, organogenesis, and embryonic morphogenesis. Coordinated cell movements drive the formation of tissues and organs during development, as well as support tissue regeneration and immunological responses in adult organisms. On the other hand, abnormalities like cancer metastasis, in which cells develop invasive characteristics and spread to other tissues, are linked to dysregulation of cell migration. Understanding the molecular and genetic processes controlling cell migration is still a top priority in developmental research because of its crucial role in the context of both physiological development and diseases. The premise of this study is that immune cells move in a directed manner in response to inflammatory signals from the site of damaged tissue. Since anti-inflammatory drugs hinder cell migration, anti-inflammatory homeopathic remedies were examined to see if they might be able to prevent a group of cells from moving collectively during Drosophila oogenesis. Drosophila oogenesis serves as a great model system for analysing collective cell movement through border cell migration. The partial epithelial to mesenchymal transition seen in migrating border cells is, incidentally, similar to that seen in solid tumor metastases. Arnica montana, Arsenicum album, and Ferrum phosphoricum—three homeopathic medications frequently used to treat inflammation—were examined for their anti-migratory properties. Incubating the Drosophila egg chambers in these medications subsequently hindered the migration of border cells. Border cell movement was more effectively inhibited by Arnica montana and Arsenicum album. Subsequent investigation revealed that the JAK/STAT pathway, which controls border cell fate specification, was disrupted when egg chambers were treated with anti-inflammatory homeopathic remedies. Based on preliminary data, this study indicates that anti-inflammatory homeopathic medications

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